Author

Makayla M. Freitas

Oregon Health & Science UniversityORCID 0000-0002-8287-8428Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Eric GouauxiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

1 paper

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedJul 22, 2025

The bile acid-sensitive ion channel is gated by Ca2+-dependent conformational changes in the transmembrane domain

Makayla M. Freitas, Eric Gouaux

This study determines the structure of human BASIC with and without Ca2+ using cryo-EM and shows Ca2+-dependent conformational changes in the transmembrane domain and β-linkers, revealing how Ca2+ modulates ion flow through the channel.

3 citations

humancryo-EM

𝕏 PostBluesky