Eric Gouaux

Mapping AMPA and NMDA receptors at mouse brain hippocampal synapses by cryo-ET

The paper maps AMPA and NMDA receptors at mouse hippocampal synapses using cryo-ET, revealing their distribution and relationship to glutamate release sites.

Programmable gold nanoparticle conjugates enable precise AMPA receptor localization at brain synapses by cryo-ET

Native architecture, allosteric modulation and gating mechanism of glycine-dependent NMDA receptors

The paper investigates the structure and gating mechanism of GluN3A-containing NMDA receptors, showing how glycine activates them and how CGP-78608 modulates their activity.

AMPAR immunization induces progressive autoimmune encephalitis with autoreactive B cells in the brain

This study develops a mouse model of anti-AMPAR encephalitis and shows that autoreactive B cells and plasma cells accumulate in the brain, driving disease progression.

The bile acid-sensitive ion channel is gated by Ca2+-dependent conformational changes in the transmembrane domain

This study determines the structure of human BASIC with and without Ca2+ using cryo-EM and shows Ca2+-dependent conformational changes in the transmembrane domain and β-linkers, revealing how Ca2+ modulates ion flow through the channel.

Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

The paper develops methods to image glutamatergic synapses in hippocampal tissue using cryo-electron tomography, enabling high-resolution visualization of synaptic structures.

Structures and membrane interactions of native serotonin transporter in complexes with psychostimulants

This paper isolates and characterizes the serotonin transporter (SERT) from porcine brain, revealing its monomeric state and structural interactions with psychostimulants like methamphetamine and cocaine.

Regulated assembly and neurosteroid modulation constrain GABAA receptor pharmacology in vivo

The paper identifies three structural populations of GABAARs in mice, revealing how neurosteroids modulate receptor structure and function.

Molecular structure and conformation of stereocilia tip-links elucidated by cryo-electron tomography

This study uses cryo-electron tomography to visualize the molecular structure and conformation of tip-links in mouse stereocilia, revealing their stoichiometry and clustering.

Mechanism of gating and partial agonist action in the glycine receptor

This study investigates the molecular mechanisms of partial agonist action and conformational transitions in the glycine receptor using electrophysiology, MD simulations, and cryo-EM.

Anti-NMDA receptor encephalitis in mice induced by active immunization with conformationally-stabilized holoreceptors

This study develops an active immunization model in mice that mimics anti-NMDA receptor encephalitis, revealing neuroinflammation and immune cell involvement in disease pathogenesis.

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2 heterotrimeric GABAA receptor in complex with GABA illuminates mechanism of receptor assembly and agonist binding

The paper presents the cryo-EM structure of a triheteromeric GABAA receptor complexed with GABA, revealing mechanisms of receptor assembly and agonist binding.