A novel genetic strategy to interrogate an unknown phenotypic modifier: an Sdhc KO-Robertsonian mouse with a semi-homologous chromosome develops papillary thyroid carcinoma-like tumours
Jean‐Pierre Bayley, Heggert G Rebel, Peter Devilee
This study creates a mouse model with a modified chromosome to investigate how chromosomal structure influences tumor development, finding that specific genetic and chromosomal combinations lead to thyroid tumors.
bioRxiv · Oct 31, 2025 · PreprintCancer Biology