Bogdan A. Czerniak

Spatial IMIX integrates spatially resolved multi-omics data with sample subtypes, modeling spatial and inter-data-type correlations to identify cancer-initiating gene activities.

This study identifies molecular changes in bladder mucosa that initiate cancer, revealing inflammation's role and mutation patterns linked to early carcinogenesis.

The paper quantifies tumor-specific total mRNA expression from bulk data and shows its association with clinical outcomes across 15 cancer types.

This study identifies distinct genomic and molecular features of sarcomatoid bladder cancer, linking EMT dysregulation to aggressive behavior and immune infiltration.