Jennifer Rui Wang

An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations

This study integrates single-cell and spatial transcriptomics to identify prognostic fibroblast subpopulations in thyroid cancer progression.

Role of the ETV5/p38 signaling axis in aggressive thyroid cancer cells

This study identifies a link between the ETV5/p38 signaling axis and aggressive thyroid cancers, showing that combining p38 inhibitors with BRAF inhibitors improves treatment outcomes.

Reconstructing oral cavity tumor evolution through brush biopsy

This study shows brush biopsies can accurately reflect the genomic profile of oral premalignant lesions and their progression to OSCC, capturing most SNVs and CNAs comparable to tissue biopsies.

Subclonal mutation load predicts survival and response to immunotherapy in cancers with low to moderate tumor mutation burden

The paper develops CliPP to estimate subclonal mutation load (sML) and shows it predicts survival and immunotherapy response in cancers with low to moderate TMB.

Scalable subclonal reconstruction of cancer cells in DNA sequencing data using a penalized likelihood model

CliPP reconstructs subclonal architecture in cancer DNA sequencing data efficiently and accurately, outperforming existing methods in speed while maintaining high concordance with consensus calls.

Tumor cell total mRNA expression shapes the molecular and clinical phenotype of cancer

The paper quantifies tumor-specific total mRNA expression from bulk data and shows its association with clinical outcomes across 15 cancer types.