Ziqiao Wang

This paper introduces PGS-TRI, a framework to estimate direct and indirect polygenic effects and gene-environment interactions in case-parent trio studies, applied to autism and orofacial clefts.

This study identifies UHRF1 as a host factor that restricts HCoV-229E infection by epigenetically silencing its receptor APN, with age-related UHRF1 decline linked to increased viral susceptibility.

This paper identifies and characterizes C10, a potent SARS-CoV-2 NSP14 inhibitor with antiviral activity and host transcriptome modulation effects.

This study identifies DMBT1 as a co-receptor for SARS-CoV-2 infection and shows a SRCR-derived peptide can inhibit it.

This study identifies DAZAP2 as a pan-coronavirus restriction factor that inhibits viral entry and genomic replication, with physiological relevance confirmed in mouse models and human cells.

This study identifies GPI biosynthesis as a conserved host restriction factor against coronaviruses, with LY6E as a key antiviral effector.

This paper develops a method to jointly model gene-environment correlations and interactions using polygenic risk scores in case-control studies, showing improved performance over standard approaches in detecting breast cancer risk interactions.

Spatial IMIX integrates spatially resolved multi-omics data with sample subtypes, modeling spatial and inter-data-type correlations to identify cancer-initiating gene activities.

This study identifies molecular changes in bladder mucosa that initiate cancer, revealing inflammation's role and mutation patterns linked to early carcinogenesis.

IMIX integrates multiple omics data types using a multivariate mixture model to improve FDR control and reduce misclassification rates compared to single-omics analyses.

This study identifies distinct genomic and molecular features of sarcomatoid bladder cancer, linking EMT dysregulation to aggressive behavior and immune infiltration.