Author

Matthew Singleton

QIMR Berghofer Medical Research InstituteORCID 0000-0002-7727-2683Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Bryan W. DayiD· 2 shared Chandra ChoudhuryiD· 2 shared Dana FriessiD· 2 shared Lachlan HarrisiD· 2 shared Amanda MillariD· 1 shared Andrew P. MontgomeryiD· 1 shared Anthony Simon DoniD· 1 shared Ariadna RecasensiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

Bryan W. DayORCID

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3 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedDec 15, 2025

Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma

George L. Joun, Emma G. Kempe, Brianna Chen…·Lenka Munoz

This study identifies PRDM9 as a factor promoting survival of drug-tolerant persister cells in glioblastoma through metabolic rewiring and cholesterol biosynthesis.

12 citationstop 2%

humanChIP-seq

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Cancer BiologybioRxivPreprintJan 22, 2025

Shared molecular regulation of quiescence in neural and glioma stem cells reveals therapeutic vulnerabilities.

Chandra Choudhury, Matthew Singleton, Stephanie Brauer…·Lachlan Harris

This study identifies shared molecular mechanisms regulating quiescence in neural and glioma stem cells and suggests TGF-β inhibition as a potential therapeutic strategy.

1 citation

humanbulk RNA-seq

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GenomicsGenome MedicinePeer-reviewedMay 1, 2023

Spatial transcriptomic analysis of Sonic Hedgehog Medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition

Tuan Vo, Brad Balderson, Kahli Jones…·Laura A. Genovesi

The paper uses spatial transcriptomics to analyze how CDK4/6 inhibition affects tumor response in SHH medulloblastoma by mapping cellular states and spatial organization.

23 citations

humanmouse

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