Kapil Bharti

This paper identifies an AKT1-TERT-FOXO3-MYC transcriptional complex that drives ERphagy and proteostasis in post-mitotic RPE cells under stress.

The paper identifies resilience factors in aged mice using a genome-scale ORF screen, finding NKX2-5 variants that restore vision and reduce frailty.

The paper constructs a multi-omics single-cell atlas of human RPE and choroid, identifying cell types, aging patterns, and genetic risk factors for AMD.

This study examines how different nutrient microenvironments affect RPE cell phenotype, function, and metabolism in iPSC and fetal RPE, identifying key metabolic shifts and phenotypic changes.

This paper introduces a method to measure transepithelial resistance, capacitance, and membrane ratio using electrochemical impedance spectroscopy on epithelial tissues.

This study shows that the CFH Y402H polymorphism increases vulnerability of iPSC-RPE cells to Hydroquinone-induced oxidative stress, suggesting genetic risk predisposition rather than soluble FH effects.

The paper shows that Zfp503 is essential for RPE differentiation and optic fissure closure, with loss of function leading to uveal coloboma and altered gene expression in developing mouse eyes.

The paper integrates RNA-seq data from human eye tissues and other body tissues to identify biological processes and gene correlations, building gene networks and providing an interactive web tool.