Author

Tamar C. Demby

National Institutes of HealthORCID 0000-0002-8300-4239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Oksana GavrilovaiD· 2 shared Allison WingiD· 1 shared Asmita PramanikiD· 1 shared Bingtian Ye· 1 shared David J. WaxmaniD· 1 shared Haressh SajiiriD· 1 shared Hongyi CaiiD· 1 shared Hye‐Kyung LeeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPhysiology

Oksana GavrilovaORCID

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2 papers

Recent·Most cited

P2Y14 receptor agonist impairs, and antagonist improves whole-body glucose homeostasis and liver steatosis

Asmita Pramanik, Siva Hariprasad Kurma, Zhiwei Wen, Hongyi Cai, Pierre-Christian Violet, Peter J. Walter, Tamar C. Demby, Oksana Gavrilova, Srinivas Pittala, Haressh Sajiir, Regina Umarova, Allison Wing, Yaron Rotman, Jürgen Wess, Kenneth A. Jacobson

This study shows that activating P2Y14R worsens glucose homeostasis and liver steatosis, while antagonizing it improves these conditions in obese mice.

bioRxiv · Sep 5, 2026 · PreprintPhysiology

Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism

Hye‐Kyung Lee, Maxim Pyatkov, Oksana Gavrilova, Naili Liu, Tamar C. Demby, Bingtian Ye, Priscilla A. Furth, Lothar G. Hennighausen, David J. Waxman

This study investigates the metabolic and gene expression effects of gain- and loss-of-function STAT5B variants in mice, revealing distinct impacts on lipid metabolism and hepatic sexual dimorphism.

Endocrinology · May 3, 2026Peer-reviewedGenomics