Author
Duke UniversityORCID 0000-0002-8322-0257Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Summer J. Harris, Oyindamola O. Adefisayo, Rachel K. Meade…·Clare M. Smith
This study shows that CCR6 is critical for controlling Mycobacterium tuberculosis infection in mice, with CCR6 deficiency leading to increased bacterial burden, inflammation, and mortality, especially in females.
Mohab Helmy, Jin U. Li, Xinyu F. Yan…·Thomas Keane
The paper presents a mouse pangenome with 17 strains, resolving structural complexity and improving RNA-Seq analysis by identifying non-reference genes and VNTR polymorphisms.
Rachel K. Meade, Oyindamola O. Adefisayo, Marco Túlio Pardini Gontijo…·Clare M. Smith
This study identifies cathepsin Z as a susceptibility factor for tuberculosis severity in both mice and humans, showing its role in disease outcomes through genetic and cellular analyses.
Rachel K. Meade, Jarukit Edward Long, Adrián Jinich…·Clare M. Smith
The paper uses transposon mutagenesis and QTL mapping to identify host-pathogen genetic interactions affecting Mtb fitness in immunodivergent mice.
Clare M. Smith, Richard E Baker, Megan K. Proulx…·Christopher M. Sassetti
This study identifies host-pathogen genetic interactions influencing tuberculosis susceptibility using a genetically diverse mouse panel and Mtb mutants.