Megan K. Proulx

Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction.

This study identifies protective antibodies against Mycobacterium tuberculosis and shows that their Fc-effector function and Fab domains collaborate to restrict infection through immune cell reorganization.

Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection

This study identifies in vivo chemical-genetic interactions in tuberculosis that reveal novel drug targets and mechanisms, showing differences from in vitro results and highlighting metabolic dependencies affecting drug efficacy.

Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance

This study identifies Raver1 as a regulator of Ripk1 RNA splicing, which affects caspase-8-mediated pyroptosis, inflammation, and resistance to Yersinia infection.

The Updated Mouse Universal Genotyping Array Bioinformatic Pipeline Improves Genetic QC in Laboratory Mice

The paper updates the MiniMUGA genotyping array's bioinformatic pipeline to enhance genetic QC in laboratory mice by improving marker annotation, consensus genotypes, and report usability.

Host-pathogen genetic interactions underlie tuberculosis susceptibility

This study identifies host-pathogen genetic interactions influencing tuberculosis susceptibility using a genetically diverse mouse panel and Mtb mutants.