In vivo Auto-tuning of Antibody-Drug Conjugate Delivery for Effective Immunotherapy using High-Avidity, Low-Affinity Antibodies
Anna Kopp, Shujun Dong, Hyeyoung Kwon, Tiexin Wang, Alec A. Desai, Andrew Philippart, Dong Jun Koo, Jennifer J. Linderman, Peter M. Tessier, Greg M. Thurber
This study develops HALA antibodies that adjust ADC delivery based on tumor HER2 expression, improving efficacy across varying expression levels in preclinical models.
Molecular Cancer Therapeutics · Dec 30, 2025Peer-reviewedBioengineering