Mechanistic Insights into the Inhibition of Recombinant Hepatitis E Virus Papain-like Cysteine Protease by Khaya grandifoliola Hydro-Ethanolic Extract: UHPLC-MS Profiling, Enzyme Kinetics, Computational Modeling, and Cell-Based Assays
Arnaud Fondjo Kouam, Cromwel Tepap Zemnou, Armel Jackson Seukep, Babayemi Olawale Oladejo, Fredy Brice Nemg Simo, Kerinyuy Juliene Kongnyuy, Armelle Gaelle Kwesseu Fepa, Elisabeth Zeuko’o Menkem, Frédéric Nico Njayou, Paul Fewou Moundipa
This study identifies Khaya grandifoliola hydro-ethanolic extract as a potent inhibitor of HEV-PLpro protease, with anti-HEV activity comparable to ribavirin and no cytotoxicity.
Fitoterapia · Jun 16, 2026Peer-reviewedBiochemistry