Author

Bruno Stegani

University of MilanORCID 0009-0008-7429-2145Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Carlo CamilloniiD· 2 shared Riccardo CapelliiD· 2 shared Alessio BonucciiD· 1 shared Camilla ArdizzoneiD· 1 shared Federico BallabioiD· 1 shared Fran Bačić ToplekiD· 1 shared Guillaume GerbaudiD· 1 shared Loic Girois· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

Carlo CamilloniORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 22, 2026

Calcium-Driven Activation of Gelsolin: Mechanism and the Active-State Ensemble

Bruno Stegani, Loic Girois, Federico Ballabio…·Matteo de Rosa

This study elucidates the mechanism of gelsolin activation through a combination of experimental and computational methods, revealing a dynamic, domain-dependent process leading to a heterogeneous active-state ensemble.

DOI 10.64898/2026.10.16.759396

experimental assaystatistical model

BiochemistrybioRxivPreprintSep 14, 2026

Assessing multi-eGO Predictions of PDZ2-Peptide Binding across Mutations

Camilla Ardizzone, Bruno Stegani, Fran Bačić Toplek…·Carlo Camilloni

This study evaluates multi-eGO's ability to predict PDZ2-peptide binding changes across mutations, showing good thermodynamic agreement but limited kinetic accuracy.

DOI 10.64898/2026.09.10.750618

protein structuredeep learning