Lianghua Wang

CELLSWARM uses LLM-driven agents to simulate tumor microenvironment dynamics, outperforming rule-based models in cross-cancer generalization and sensing indirect genetic perturbations.

The paper develops a computational method to guide the cyclization of saxitoxin aptamers, showing that circular aptamers have higher affinity and improved survival in mice.

This paper models and simulates the interaction between palytoxin and its aptamer, showing strong hydrogen-bonding and electrostatic interactions in the DNA groove.