Reversible CD28 checkpoint modulation by cyclic peptides outperforms biologic blockade under exposure-limited conditions
Katarzyna Kuncewicz, Saurabh Upadhyay, Yutong Ge, Hong Quan Duan, Moustafa Tarek Gabr
This study introduces CP8, a cyclic peptide that effectively blocks CD28 co-stimulation and allows rapid restoration of T-cell function, outperforming existing biologics under exposure-limited conditions.
bioRxiv · Apr 13, 2026 · PreprintPharmacology & Toxicology