Author

Yutong Ge

Macao Polytechnic UniversityORCID 0000-0002-6375-7559Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Hongliang DuaniD· 2 shared Moustafa Tarek GabriD· 2 shared Ashraf Abdo· 1 shared Chengyun ZhangiD· 1 shared Chongyang LiiD· 1 shared Hanjie Yang· 1 shared Hong Quan DuaniD· 1 shared Hongli HouiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioinformatics

Hongliang DuanORCID

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3 papers

Recent·Most cited

HighFold-Lasso: Topology-Guided Prediction of Lasso Peptide Structures Using AlphaFold3

Sen Cao, Chengyun Zhang, Hanjie Yang, Yutong Ge, Hongli Hou, Zhu Ning, Yaling Wu, Jisong Mo, Juan Guo, Chongyang Li, JINGJING GUO, Hongliang Duan

HighFold-Lasso predicts lasso peptide structures using topology-guided methods, achieving perfect topology success and low RMSD on a test set of 52 structures.

bioRxiv · Oct 16, 2026 · PreprintBioinformatics

A First-in-Class, Brain-Penetrant Small Molecule Inhibitor of the NOS1AP-Tau Interaction Rescues Tau Pathology In Vivo and Improves Cognition

Ashraf Abdo, Sungwoo Cho, Yutong Ge, Hongliang Duan, Moustafa Tarek Gabr

CAPTOR-1, a small molecule inhibitor of NOS1AP-tau interaction, reduces tau pathology and improves cognition in AD models.

bioRxiv · Oct 7, 2026 · PreprintPharmacology & Toxicology

Reversible CD28 checkpoint modulation by cyclic peptides outperforms biologic blockade under exposure-limited conditions

Katarzyna Kuncewicz, Saurabh Upadhyay, Yutong Ge, Hong Quan Duan, Moustafa Tarek Gabr

This study introduces CP8, a cyclic peptide that effectively blocks CD28 co-stimulation and allows rapid restoration of T-cell function, outperforming existing biologics under exposure-limited conditions.

bioRxiv · Apr 13, 2026 · PreprintPharmacology & Toxicology