John B. Sunwoo

This study uses CRISPR activation screening to identify surface ligands that regulate tumor sensitivity to NK cell killing, revealing new targets for improving NK cell-based immunotherapies.

LabOS is an AI co-scientist that integrates computational reasoning with physical experimentation through multimodal perception and human-AI collaboration, enhancing scientific discovery in biomedical and materials science.

This study identifies ACTL6A as a regulator of hypoxic adaptation and metabolic plasticity in head and neck squamous cell carcinoma by modulating AP-1 signaling and chromatin structure.

This study uses an alphavirus replicon particle expressing IL-12 to reprogram immunosuppressive tumor-associated macrophages and neutrophils, enhancing anti-tumor immunity and reducing tumor growth in mouse models.

MONTAGE identifies spatially resolved functional enrichment gradients in tumor microenvironments by analyzing spatial communities and their clinical relevance.

The paper integrates multiplexed imaging and multiscale modeling to show that T cell phenotype influences tumor phenotype conversion, critical for therapeutic efficacy.

7-UP generates in silico 40-plex CODEX data from a 7-plex mIF panel using cellular morphology, enabling cell type classification and survival prediction across diverse samples.

CELESTA identifies cell types in multiplexed in situ images by integrating protein expression and spatial information, revealing novel spatial biology associated with lymph node metastasis.