Type I interferon signaling instills divergent metastatic phenotypes and immunotherapy responses
Cort B. Breuer, Marcos Labrado, Grayson E. Rodriguez, K. Christopher García, Nathan Edward Reticker-Flynn
This study identifies opposing roles of type I interferon signaling in promoting lymph node metastasis while inhibiting distant organ metastasis and enhancing immunotherapy response.
bioRxiv · Sep 18, 2025 · PreprintCancer Biology