Joseph C. Wu

Metabolic Perturbation Exacerbates Sinoatrial Node Dysfunction in Heart Failure

This study identifies ceramides as mediators of mitochondrial dysfunction in sinoatrial node cells during heart failure, suggesting they as potential therapeutic targets.

Generation of an induced pluripotent stem cell line from a patient with immune checkpoint inhibitor-induced myocarditis and concurrent type I diabetes

The paper describes the generation of an iPSC line from a patient with immune checkpoint inhibitor-induced myocarditis and type I diabetes, highlighting its pluripotency and potential for studying disease mechanisms.

Damaging RBM20 E-rich domain variants are not rescued by gene replacement

The paper investigates E-rich domain variants of RBM20, showing they reduce protein abundance and cause splicing defects, but are not rescued by RBM20 overexpression.

Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed

The paper analyzes expression and splicing quantitative trait loci (e/sQTL) across multiple tissues in the TOPMed dataset and finds that secondary e/sQTL signals are still discoverable, with many GWAS signals colocalizing with these e/sQTL.

Generation of three induced pluripotent stem cell lines from an immune checkpoint inhibitor-induced myocarditis patient and controls

The paper generates three iPSC lines from an ICIM patient and controls to study disease mechanisms and develop therapies.

A multi-omics map of diabetic nephropathy links c-Jun activation to tubular injury and metabolic stress

This study integrates multi-omics data to identify c-Jun as a key driver of tubular injury and fibrosis in diabetic nephropathy.

Beta-Adrenergic Stimulation and MYH7 G256E Mutant Gene Dosage Drive Hypertrophic Cardiomyopathy Phenotype Penetrance

This study investigates factors influencing HCM phenotype penetrance by comparing MYH7 mutations in isogenic hiPSC-CMs and shows that beta-adrenergic stimulation and gene dosage affect disease expression.

CES1 DEFICIENCY IS ASSOCIATED WITH METABOLIC REPROGRAMING AND ENDOTHELIAL DYSFUNCTION IN PULMONARY ARTERIAL HYPERTENSION

This study identifies CES1 deficiency as a driver of metabolic reprogramming and endothelial dysfunction in pulmonary arterial hypertension, showing its role in lipid metabolism and oxidative stress.

Dual Mechanism of Action: Exosomes from Human iPSC-Cardiomyocytes and Mesenchymal Stem Cells Restore Injured Myocardium

This study shows that exosomes from human iPSC-cardiomyocytes and mesenchymal stem cells improve heart function after myocardial infarction in pigs, with distinct miRNA mechanisms.

LabOS: The AI-XR Co-Scientist That Sees and Works With Humans

LabOS is an AI co-scientist that integrates computational reasoning with physical experimentation through multimodal perception and human-AI collaboration, enhancing scientific discovery in biomedical and materials science.

Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brain

The paper identifies age-related microbiome metabolites that alter RNA splicing and chromatin accessibility in the mouse brain using metabolomics, transcriptomic, and multi-omic approaches.

ACTL6A regulates the Warburg effect through coordinated activation of AP-1 signaling in head and neck squamous cell carcinoma

This study identifies ACTL6A as a regulator of hypoxic adaptation and metabolic plasticity in head and neck squamous cell carcinoma by modulating AP-1 signaling and chromatin structure.

Micropatterned Organoids Enable Modeling of the Earliest Stages of Human Cardiac Vascularization

The paper demonstrates that micropatterned human pluripotent stem cells can model early human cardiac vascularization in vitro, resembling a 6.5 post-conception week heart and revealing conserved vascular development programs.

A primate model organism for cardiac arrhythmias identifies a magnesium transporter in pacemaker function

The paper identifies a magnesium transporter, SLC41A2, as critical for primate cardiac pacemaker function using a mouse lemur model of arrhythmias.

Specialized Pericyte Subtypes in the Pulmonary Capillary

The paper identifies two specialized pericyte subtypes in pulmonary capillaries using Higd1b as a marker and shows their distinct functions and responses to hypoxia.

Membrane Curvature Promotes ER-PM Contact Formation via Junctophilin-EHD Interactions

This study shows PM curvature promotes ER-PM contact formation in cardiomyocytes via junctophilin-EHD interactions.

ADMET-AI: A machine learning ADMET platform for evaluation of large-scale chemical libraries

ADMET-AI, a Chemprop-RDKit graph neural network trained on 41 TDC datasets, has the best average leaderboard rank and scores one million molecules in 3.1 hours.

Personalized transcriptome signatures in a cardiomyopathy stem cell biobank

The paper establishes a cardiomyopathy stem cell biobank and identifies transcriptomic subtypes and drug response in iPSC-derived cardiomyocytes.

Mitigation of Stress-induced Structural Remodeling and Functional Deficiency in iPSC-CMs with PLN R9C Mutation by Promoting Autophagy

This study investigates how the PLN R9C mutation affects iPSC-CMs and shows that promoting autophagy can mitigate stress-induced structural and functional defects in these cells.

Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration

This study investigates the effects of the MYH7 G256E mutation on myosin function across multiple scales, finding increased hypercontractility and mitochondrial respiration.

Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease

This study uses single-cell chromatin accessibility analysis to identify developmental trajectories and non-coding mutations associated with congenital heart disease.

KMT2D-NOTCH Mediates Coronary Abnormalities in Hypoplastic Left Heart Syndrome

This study identifies KMT2D-NOTCH signaling defects in HLHS coronary artery endothelial cells, showing impaired differentiation and proliferation due to suppressed NOTCH target genes.

Systems Analysis of de novo Mutations in Congenital Heart Diseases Identified a Molecular Network in Hypoplastic Left Heart Syndrome

The paper uses systems analysis to identify a molecular network in hypoplastic left heart syndrome, revealing novel factors and mechanisms through integration of genomic and transcriptomic data.

Endocardial/endothelial angiocrines regulate cardiomyocyte development and maturation and induce features of ventricular non-compaction

This study identifies angiocrine factors secreted by endocardial and endothelial cells that regulate cardiomyocyte development and maturation, contributing to ventricular non-compaction in Ino80-deficient mouse hearts.

Endothelial CXCL12 regulates neovascularization during tissue repair and tumor progression

This study shows that endothelial CXCL12 is crucial for neovascularization in tissue repair and tumor progression by regulating endothelial-fibroblast interactions and recruiting neovascularization-supporting cells.

Tyrosine kinase inhibitors induce mitochondrial dysfunction during cardiomyocyte differentiation through alteration of GATA4-mediated networks

This study shows that tyrosine kinase inhibitors cause mitochondrial dysfunction in cardiomyocytes by altering GATA4-mediated networks, and GATA4 overexpression can rescue these effects.

Splice junction-centric approach to identify translated noncanonical isoforms in the human proteome

The paper identifies translated noncanonical isoforms in the human proteome using a splice junction-centric approach and mass spectrometry data.

Single-Cell RNA-Seq Reveals Endocardial Defect in Hypoplastic Left Heart Syndrome

This study uses single-cell RNA sequencing to identify endocardial defects in hypoplastic left heart syndrome, linking them to abnormal valve and septum development.

Toxicogenomic identification of repositioned therapy for a monogenic disease

The paper uses transcriptomic data to identify potential drug therapies for a monogenic disease by finding FDA-approved drugs with similar transcriptional profiles.

Dissociation of disease phenotype and allele silencing in hypertrophic cardiomyopathy

This study compares two allele-specific silencing strategies in a human model of hypertrophic cardiomyopathy, finding that reducing both alleles improves contractility more than targeting only the disease allele.