Author

Daniel J. Rolfe

Rutherford Appleton LaboratoryORCID 0000-0002-8394-8395Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Research Focus:imputation· 1 Organism:mouse· 1

Frequent Co-Authors

David T. ClarkeiD· 2 shared Laura C. Zanetti-DominguesiD· 2 shared Marisa L. Martin-FernandeziD· 2 shared Sarah R. NeedhamiD· 2 shared Amy N. Moores· 1 shared Andrew H. A. ClaytoniD· 1 shared Benjamin Michael DavisiD· 1 shared Benji Bateman· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

David T. ClarkeORCID

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Author profile →

2 papers

Recent·Most cited

Disrupting aberrant EGFR catalytic trimers reverses T790M gefitinib resistance

Selene K. Roberts, Ioannis Galdadas, Nicola Piasentin, Sarah R. Needham, Benjamin Michael Davis, Laura C. Zanetti-Domingues, Rico C.H. Man, David T. Clarke, Andrew H. A. Clayton, Daniel J. Rolfe, Gilbert O. Fruhwirth, Francesco Luigi Gervasio, Marisa L. Martin-Fernandez

This study shows that disrupting pathological EGFR catalytic trimers reverses gefitinib resistance by rewiring signaling and slowing tumor growth.

bioRxiv · Sep 30, 2026 · PreprintCancer Biology

Solid immersion microscopy readily and inexpensively enables 12 nm resolution on plunge-frozen cells

Lin Wang, Benji Bateman, Laura C. Zanetti-Domingues, Amy N. Moores, Sam Astbury, Christopher Spindloe, Michele C. Darrow, Maria Romano, Sarah R. Needham, Konstantinos Beis, Daniel J. Rolfe, David T. Clarke, Marisa L. Martin-Fernandez

This paper introduces a low-cost solid immersion lens technique that achieves 12 nm resolution in cryogenic fluorescence microscopy, outperforming more expensive systems.

bioRxiv · Jul 20, 2018 · PreprintBiophysics