Sarah R. Needham

This study shows that disrupting pathological EGFR catalytic trimers reverses gefitinib resistance by rewiring signaling and slowing tumor growth.

The paper identifies a unique pericystic endothelium in ADPKD that contributes to microvascular remodelling and impaired perfusion, suggesting vascular targets for early intervention.

This paper introduces a low-cost solid immersion lens technique that achieves 12 nm resolution in cryogenic fluorescence microscopy, outperforming more expensive systems.