Cell BiologyNature Structural & Molecular BiologyPeer-reviewed
Initiation of ERAD by the bifunctional complex of Mnl1 mannosidase and protein disulfide isomerase
Dan Zhao, Xudong Wu, Tom A. Rapoport
The paper shows the Mnl1-Pdi1 complex initiates ERAD by de-mannosylating misfolded proteins and reducing their disulfides, enabling translocation for proteasomal degradation.
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