Mario Zurita

Inhibition of TFIIH translocase reveals a novel lncRNA regulatory network at the BRCA1 locus

The paper identifies a novel lncRNA regulatory network at the BRCA1 locus that is activated during transcriptional stress induced by XPB inhibition.

Transcriptional stress induces the generation of DoGs in cancer cells.

The paper shows that transcription inhibition in cancer cells leads to the generation of DoGs, suggesting they are part of a cellular stress response.

Different transcriptional responses by the CRISPRa system in distinct types of heterochromatin in Drosophila melanogaster

This study shows that the CRISPRa system can activate transcription in different types of heterochromatin in Drosophila, but the effect varies depending on the regulatory element.

Interplay between positive and negative regulation by B3-type transcription factors is critical for the accurate expression of the ABA INSENSITIVE 4 gene.

The paper identifies a regulatory circuit involving LEC2, ABI3, and HSI/VAL proteins that controls ABI4 gene expression through RY cis-acting motifs and chromatin structure in plants.

Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer

The paper shows that disrupting TFIIH activities with TPL or THZ1 increases cancer cell sensitivity and identifies potential new cancer targets.