Raphael Silveira Vidal

The paper investigates how CTCF mutations affect chromatin accessibility, cohesin binding, and gene regulation through multivariate modeling and mutant perturbations.

The paper identifies a novel lncRNA regulatory network at the BRCA1 locus that is activated during transcriptional stress induced by XPB inhibition.

This study identifies Aurora-A as a CDK12-activating kinase in neuroblastoma, showing its role in transcription termination and tumor growth suppression.

The paper shows that TFIIIC binds MYCN and limits non-phosphorylated RNA Polymerase II accumulation at promoters, but does not affect MYCN-dependent gene expression or transcription elongation.