Author

Irena Gushterova

Broad InstituteORCID 0000-0002-8405-6348Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Anna L. K. GonyeiD· 2 shared Moshe Sade-FeldmaniD· 2 shared Nir HacoheniD· 2 shared Thomas James LaSalleiD· 2 shared Alexandra–Chloé VillaniiD· 1 shared Alexis M. SchneideriD· 1 shared Amanda S. ZajaciD· 1 shared Anat O Stemmer-RachamimoviD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenomics

Anna L. K. GonyeORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma

Samuel S. Freeman, Moshe Sade-Feldman, Jaegil Kim, Chip Stewart, Anna L. K. Gonye, Arvind Ravi, Monica B. Arniella, Irena Gushterova, Thomas James LaSalle, Emily M. Blaum, Keren Yizhak, Dennie Tompers Frederick, Tatyana Y. Sharova, Ignaty Leshchiner, Liudmila Elagina, , Nir Hacohen

The paper develops DNA- and RNA-based models combining immune and tumor features to predict outcomes of checkpoint inhibition in melanoma.

Cell Reports Medicine · Feb 1, 2022Peer-reviewedGenomics

Plasma proteomics reveals tissue-specific cell death and mediators of cell-cell interactions in severe COVID-19 patients

Michael R. Filbin, Arnav Mehta, Alexis M. Schneider, Kyle R. Kays, Jamey R. Guess, Matteo Gentili, Bánk Gábor Fenyves, Nicole C. Charland, Anna L. K. Gonye, Irena Gushterova, Hargun K. Khanna, Thomas James LaSalle, Kendall M. Lavin-Parsons, Brendan M. Lilley, Carl L. Lodenstein, , Marcia B. Goldberg

The paper uses plasma proteomics to identify tissue-specific cell death and cell-cell interaction mediators in severe COVID-19 patients, linking them to survival outcomes and viral infection effects.

Cell Reports Medicine · May 1, 2021Peer-reviewedSystems Biology