Arnav Mehta

The paper identifies Trim28 as a regulator of CD8 T cell differentiation in tumors using clonally-resolved CRISPR screens and shows its role in maintaining TCF7+ stem-like cells while impairing effector differentiation.

The paper analyzes transcriptomic changes in metastatic pancreatic cancer using a patient's autopsy data to identify site-specific gene programs and clonal phylogeny.

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

The paper uses plasma proteomics to identify tissue-specific cell death and cell-cell interaction mediators in severe COVID-19 patients, linking them to survival outcomes and viral infection effects.

This study uses single-nucleus and spatial transcriptomics to analyze pancreatic cancer before and after neoadjuvant treatment, revealing changes in cell states and immune infiltration that may inform therapy.

The paper shows that stochastic cis-acting events at the Bcl11b locus control T-cell lineage commitment dynamics through a delay in gene activation.