Marcia B. Goldberg

The paper identifies and validates a consensus substrate recognition motif for Shigella OspB, revealing key amino acid positions critical for its protease activity.

This study identifies NLRP11 as a primate-specific factor that enhances CASP4-mediated cLPS detection and non-canonical inflammasome activation in human macrophages.

This study shows that human macrophages use both NLRC4 and non-canonical inflammasome pathways to kill Shigella flexneri without causing cell death, independent of bacterial cardiolipin.

The paper identifies 14-3-3ζ and CAP2 as host proteins required for actin remodeling during Shigella flexneri entry, showing their coordinated role in membrane ruffle formation.

This study shows that IpaC forms a translocation-competent pore essential for Shigella flexneri to escape double membrane vacuoles during intercellular spread.

This study uses metagenomic sequencing to detect pathogens in CNS infections, identifying novel pathogens and improving detection methods.

The paper uses plasma proteomics to identify tissue-specific cell death and cell-cell interaction mediators in severe COVID-19 patients, linking them to survival outcomes and viral infection effects.