David S. Pellman

In S. japonicus, the ESCRT adaptor Alx1 activates the essential PH-domain protein Vid27 through interaction, driving postmitotic nuclear envelope sealing independently of Cmp7 and ESCRT-III.

The paper identifies a phospho-switch mechanism that reprograms TRAIP to ubiquitylate replisomes in mitosis, enabling disassembly of unreplicated DNA.

This study shows that the TIRR-53BP1 axis regulates PLK1 activity during mitosis, affecting chromosome segregation and kinetochore assembly.

This paper introduces refLinker, a method for haplotype-resolved analysis of cancer karyotypes, revealing transcriptional consequences of somatic Xi rearrangements.

The paper identifies breakage-replication/fusion as a mechanism causing DNA duplications and insertions, unifying explanations for complex rearrangements and enabling rapid DNA amplification.

This paper shows that CRISPR-Cas9-induced DNA breaks can lead to chromothripsis, a catastrophic chromosomal rearrangement, which is an on-target toxicity in genome editing.

This study analyzes chromothripsis in 2,658 cancers using whole-genome sequencing, finding it prevalent across multiple cancer types with complex structural alterations.