Cell BiologybioRxivPreprint
Immune-Derived THBS1-CD47 Axis Induces Cellular Senescence and Suppresses Osteogenesis in Diabetic Periosteum
Fangyuan Shen, Jianpeng Zhou, Moyu Liu…·Yu Shi
This study identifies the THBS1-CD47 axis as a driver of periosteal dysfunction in T2DM, showing it induces cellular senescence and suppresses osteogenesis, with therapeutic potential in diabetic bone repair.
DOI 10.1101/2025.11.19.689158