Cancer BiologybioRxivPreprint
Targeting the CDK4-Cyclin D Complex: A New Generation of Selective Kinase Inhibitors for Cancer Therapy
María Fuentes-Baile, José Antonio Encinar, Salomé Araujo‐Abad…·Miguel Saceda
This paper identifies a novel CDK4 inhibitor, diophenic, that selectively targets the CDK4-Cyclin D1 interaction, showing improved selectivity and reduced off-target effects compared to ATP-competitive inhibitors in GBM models.
DOI 10.64898/2026.09.18.752547