CAR-Engineered Human Hematopoietic Stem Cell Macrophages Control Solid Tumors
Ian Ovider, Lívia Furquim de Castro, Carla Fogolin, Leonel Witcoski, Viviane Jennifer da Silva, Akash Samuel Carasala, Elisa Lie M. Matsumura, Lucas Brito de Souza Santos, Vinícius Alex Cano Pereira, Gabriela C. M. Evangelista, Théo Gremen Mimary de Oliveira, Samuel Campanelli Freitas Couto, Rossana Pulcineli Vieira Francisco, Adriana Franco Paes Leme, Tárcio Teodoro Braga, , Rodrigo Nalio Ramos
This study generates CAR-engineered macrophages from human HSCs to target solid tumors, showing enhanced phagocytic activity and tumor control in vitro and in vivo.
bioRxiv · May 29, 2026 · PreprintImmunology