Guilherme P. F. Nader

This study develops a model linking nuclear hydration to chromatin phase organization and mechanics, showing how osmotic and mechanical cues influence chromatin structure through water content and histone dynamics.

This study proposes a physical model of the nucleus that explains its mechanical behavior under deformation, highlighting the role of the envelope and chromatin in nuclear mechanics.

This study generates CAR-engineered macrophages from human HSCs to target solid tumors, showing enhanced phagocytic activity and tumor control in vitro and in vivo.

The paper shows that cell confinement causes delayed, heritable chromosome loss, which is linked to mitotic memory and has implications for cancer evolution.

This study identifies metabolic starvation-induced cell swelling as the primary driver of solid stress in tumors, revealing a mechanical basis for genomic instability and treatment resistance.

This study identifies KIF3AC and RCP as essential for recycling integrin from disassembled focal adhesions to promote polarized FA formation at the leading edge of migrating fibroblasts.