VEGF-A/VEGFR-1: a painful astrocyte-mediated signaling blocked by the anti-VEGFR-1 mAb D16F7
Laura Micheli, Carmen Parisio, Elena Lucarini, Alessia Vona, Alessandra Toti, Alessandra Pacini, Tommaso Mello, Serena Boccella, Flavia Ricciardi, Sabatino Maione, Grazia Graziani, Pedro Miguel Lacal, Paola Failli, Carla Ghelardini, Lorenzo Di Cesare Mannelli
This study identifies VEGF-A released by astrocytes as a key mediator of chemotherapy-induced neuropathic pain and shows that the anti-VEGFR-1 mAb D16F7 alleviates this pain.
bioRxiv · Jan 19, 2021 · PreprintNeuroscience