Plasticity of squamous differentiation drives drug resistance in HNSCC
Kalle H. Sipilä, Matteo Vietri Rudan, Priyanka G. Bhosale, Matthew Blakeley, Clarisse Gânier, Robert Kennedy, Emanuel Rognoni, Fiona M. Watt
This study shows that some HNSCC cells resist differentiation despite being capable of it, highlighting a barrier to differentiation-based therapies.
bioRxiv · Mar 11, 2026 · PreprintCancer Biology