Arunava Roy

Decoding the molecular cues regulating the transition of Influenza virus polymerase from transcriptase to replicase.

This study identifies interdomain interactions in PB2 that regulate Influenza virus polymerase conformational transitions and transcription-replication balance, revealing a phosphomimetic adaptation mechanism in bat influenza viruses.

Influenza virus recruits PKCa-MEK1-ERK2 complex to regulate nuclear export of viral ribonucleoproteins and promote virus replication.

This study identifies a PKC-MEK1-ERK2 complex that phosphorylates viral NP, facilitating RNP nuclear export and virus replication.

Inhibition of SARS-CoV-2 spike protein palmitoylation reduces virus infectivity

This study shows that inhibiting SARS-CoV-2 spike protein palmitoylation reduces virus infectivity by disrupting trimerization and membrane fusion.