The paper identifies novel compounds that reduce lipid droplet accumulation in podocytes by inducing lipophagy, offering potential therapeutic benefits for lipid metabolism disorders.

ACS Chemical Biology · Jun 2, 2025Peer-reviewedCell Biology

Structure-activity relationship of pyrrolidine pentamine derivatives as inhibitors of the aminoglycoside 6'-N-acetyltransferase type Ib

Jan Sklenicka, Tung Tran, María Soledad Ramirez, Haley M. Donow, Angel J. Magaña, Travis M. Lavoi, Yasir Mamun, Verónica Jiménez, Prem P. Chapagain, Radleigh G. Santos, Clemencia Pinilla, Marc A. Giulianotti, Marcelo E. Tolmasky

This study identifies pyrrolidine pentamine derivatives as inhibitors of AAC(6')-Ib, showing that structural modifications affect inhibitory activity and that molecular docking correlates with potency.

Antibiotics · Jul 19, 2024Peer-reviewedBiochemistry

Inhibition of SARS-CoV-2 spike protein palmitoylation reduces virus infectivity

Ahmed Ramadan, Karthick Mayilsamy, Andrew R. McGill, Anandita Ghosh, Marc A. Giulianotti, Haley M. Donow, Shyam S. Mohapatra, Subhra Mohapatra, Bala Chandran, Robert J. Deschenes, Arunava Roy

This study shows that inhibiting SARS-CoV-2 spike protein palmitoylation reduces virus infectivity by disrupting trimerization and membrane fusion.

bioRxiv · Oct 7, 2021 · PreprintMolecular Biology