A Back-Door Insights into the modulation of Src kinase activity by the polyamine spermidine
Sofia Rossini, Marco Gargaro, Giulia Scalisi, Elisa Bianconi, Sara Ambrosino, Eleonora Panfili, Claudia Volpi, Ciriana Orabona, Antonio Macchiarulo, Francesca Fallarino, Giada Mondanelli
This study identifies spermidine as a positive allosteric modulator of Src kinase by binding to a novel site on the SH2 domain, enhancing its interaction with IDO1.
eLife · Jun 30, 2023Peer-reviewedMolecular Biology