Enzyme family-centred approach identifies helicases as recurrent hemizygous tumour suppressor genes
Karolin Voßgröne, Francesco Favero, Krushanka Kashyap, Francisco German Rodriguez Gonzalez, André Vidas Olsen, Xin Li, Balca R. Mardin, Joachim Weischenfeldt, Claus Storgaard Sørensen
The paper identifies helicases as frequently mutated enzyme families in cancer, showing their role in genomic instability and DNA repair defects, with AQR as a novel hemizygous tumor suppressor.
Science Advances · Feb 20, 2026Peer-reviewedCancer Biology