Tim J. Fennell

The paper develops and validates methods to detect off-target recombination by Large Serine Integrases, finding higher sensitivity than whole genome sequencing.

The paper introduces a windowed kinship algorithm using sparse SNPs to estimate kinship in forensic genetics, achieving performance comparable to segment matching with fewer false associations.

Crosscheck detects mislabeled samples in NGS data by analyzing linkage disequilibrium, correcting errors in 1% of ENCODE datasets.

Per-sample assembly with gVCF output, followed by joint genotyping, lets GATK HaplotypeCaller scale linearly with cohort size while calling indels more accurately than SAMtools, UnifiedGenotyper or Platypus.

The paper critiques the experimental design and data interpretation in a previous study claiming CRISPR-Cas9 causes unexpected mutations, arguing the conclusions are not supported by the evidence.