Anne M. Bara

Mutually Repressive Transcription Factors Drive Intestinal Maturation for Weaning

This study identifies BLIMP1 and CASZ1 as mutually repressive transcription factors that regulate intestinal enterocyte maturation during weaning and corticosteroid-induced maturation.

Designing AI-programmable therapeutics with the EDEN family of foundation models

This paper introduces the EDEN family of foundation models for AI-programmable therapeutic design, demonstrating their ability to generate functional gene insertions, antibiotic peptides, and synthetic microbiomes.

Highly Efficient Multiplexed Genome Engineering and Clone Selection to Enable Next Generation Induced Pluripotent Stem Cell (iPSC)-based Cell Therapies

This paper introduces a novel genome engineering method for iPSCs that enables efficient multiplex gene editing and clone selection, improving the precision and speed of iPSC-based therapies.

Large Serine Integrase Off-Target Discovery with Deep Learning for Genome Wide Prediction

The paper introduces IntQuery, a deep learning model that predicts LSI off-target activity genome-wide using data from Cryptic-seq.

Large Serine Integrase Off-target Discovery and Validation for Therapeutic Genome Editing

The paper develops and validates methods to detect off-target recombination by Large Serine Integrases, finding higher sensitivity than whole genome sequencing.

The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia

This study investigates how the 22q11.2 deletion affects gene expression in neural progenitor cells and neurons, linking it to schizophrenia risk through altered presynaptic gene products.

FMR1 loss results in early changes to intrinsic membrane excitability in human cellular models

This study examines the effects of FMR1 loss on intrinsic membrane excitability in human cortical neurons using isogenic hPSC models, finding early and transient changes in electrophysiological properties.