Bing He

Early zygotic gene product Dunk interacts with anillin to regulate Myosin II during Drosophila cleavage

This study identifies Dunk as a regulator of myosin II during Drosophila cellularization by interacting with anillin to control its localization and function.

PI 4-kinases promote cell surface expansion and facilitate tissue morphogenesis during Drosophila cellularization and gastrulation

The paper identifies Fwd as a PI 4-kinase that regulates cell surface expansion during Drosophila epithelial morphogenesis, showing its role in apical constriction and tissue formation.

Dlg1 regulates subcellular distribution of non-muscle myosin II during Drosophila germband extension

This study shows that Dlg1 regulates myosin II subcellular distribution during Drosophila germband extension, affecting cell intercalation and junctional remodeling.

Cell polarity determinant Dlg1 facilitates epithelial invagination by promoting tissue-scale mechanical coordination

The paper shows that Dlg1 in flanking cells is essential for epithelial invagination by enabling mechanical coordination during apical constriction.

Actomyosin activity-dependent apical targeting of Rab11 vesicles reinforces apical constriction

The paper identifies an actomyosin-dependent mechanism where Rab11 vesicles accumulate apically during Drosophila mesoderm invagination, enhancing apical constriction by maintaining adherens junction integrity.

Mechanical bistability of the mesoderm epithelium facilitates mesoderm invagination during Drosophila gastrulation

The paper shows that myosin contractility is critical for early mesoderm invagination but not for the folding step, suggesting mechanical bistability in Drosophila gastrulation.