Jiayang Chen

A survey of hypothalamic phenotypes identifies molecular and behavioral consequences of MYT1L haploinsufficiency in male and female mice.

This study examines the molecular and behavioral effects of MYT1L haploinsufficiency in mice, finding region-specific hypothalamic disruptions and sex-specific behavioral stability.

A single binge ethanol exposure is apoptotic within hours across neurodevelopment and partially regulated by the Myt1l gene.

The paper shows a single binge ethanol exposure rapidly increases apoptosis in early adolescent and adult mice, with Myt1l haploinsufficiency modulating this effect across developmental stages.

MYT1L deficiency impairs excitatory neuron trajectory during cortical development

This study examines the role of MYT1L in neuronal development by analyzing gene expression in wild-type and MYT1L-deficient mice, finding disruptions in excitatory neuron proportions and gene expression.

Early zygotic gene product Dunk interacts with anillin to regulate Myosin II during Drosophila cleavage

This study identifies Dunk as a regulator of myosin II during Drosophila cellularization by interacting with anillin to control its localization and function.

AcrNET: Predicting Anti-CRISPR with Deep Learning

AcrNET predicts anti-CRISPR proteins using a deep learning model, achieving significant performance improvements and class-level predictions.

MYT1L is required for suppressing earlier neuronal development programs in the adult mouse brain

The paper investigates MYT1L's role in suppressing earlier neuronal development programs in the adult mouse brain, showing it regulates gene expression and chromatin structure in cortical neurons.

Interpretable RNA Foundation Model from Unannotated Data for Highly Accurate RNA Structure and Function Predictions

A BERT-style model pretrained on 23.7 million unlabelled ncRNA sequences gives embeddings that improve secondary structure, contact, distance-map and some function predictions over task-specific and MSA-based baselines.

A MYT1L Syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation

This paper develops a MYT1L syndrome mouse model that recapitulates human phenotypes, revealing disrupted brain development and neuronal maturation as underlying mechanisms.