Exploring Ventilator-Induced Lung Injury: A Comprehensive Ex-Vivo Study Using Phase-Contrast MicroCT and Atomic Force Microscopy
Md Motiur Rahman Sagar, Lorenzo D’Amico, Richard T Deyhle, Ruth Meyer, Luca Fardin, Irma Mahmutovic Persson, J. L. Cercos-Pita, Gaetano Perchiazzi, Sarah Köster, Claudia Victoria Benke, Frauke Alves, Giuliana Tromba, Lars E. Olsson, Sam Bayat, Christian Dullin
This study investigates ventilator-induced lung injury in a rat model using ex-vivo imaging and mechanical analysis, finding that fibrotic lungs show reduced airspace enlargement compared to healthy lungs after injurious ventilation.
bioRxiv · Mar 3, 2026 · PreprintPathology