Sarah Köster

Desmin Mutations Disrupt Filament Elongation and Drive Polymorphic Aggregation

This study examines how desmin mutations affect filament assembly and aggregation, finding that specific mutations disrupt filament maturation and lead to distinct aggregation pathways.

In situ radiation damage tracking during scanning small-angle X-ray scattering

This paper tracks radiation damage in cells during scanning SAXS using a synchronized brightfield microscope.

Structural order emerges without mechanical order inside living cells

The paper investigates intracellular mechanical properties and structural organization in RPE1 cells, finding no significant spatial mechanical patterns or correlations between structures and mechanical properties.

Synapsin-1 and actin form ordered nanoscale assemblies

This study investigates how synapsin-1 and actin form ordered nanoscale assemblies through phase separation, showing that actin scaffolds retain structural memory for condensate reformation.

Force generation of cardiomyocytes in engineered environments

This study shows that geometric confinement and substrate stiffness influence cardiomyocyte force generation differently, with confinement enhancing contractile stress and relaxation on physiological substrates.

Interactions between single actin and vimentin filaments

This study demonstrates direct mechanical interactions between single actin and vimentin filaments, independent of crosslinking proteins, and quantifies the interaction forces.

Correlative X-ray imaging and fluorescence microscopy

This paper presents a correlative imaging platform combining fluorescence microscopy and scanning SAXS to study cellular structures in native conditions, showing agreement between label-free SAXS and labeled fluorescence data.

Bayesian Inference of Bond Parameters from Interactions between Single Filaments

The paper uses Bayesian inference to determine bond parameters between vimentin filaments from force trajectories measured with optical tweezers.

Stretching drives Membrane Homogenization of Phase-Separated Supported Lipid Bilayers

This study shows that stretching supported lipid bilayers with phase separation leads to homogenization, consistent with a second-order phase transition, indicating membrane tension regulates lateral organization.

Fast scanning small angle X-ray scattering of hydrated biological cells

This paper demonstrates fast scanning SAXS on biological cells in aqueous environments to reveal intracellular anisotropy and orientation and assess radiation damage.

Exploring Ventilator-Induced Lung Injury: A Comprehensive Ex-Vivo Study Using Phase-Contrast MicroCT and Atomic Force Microscopy

This study investigates ventilator-induced lung injury in a rat model using ex-vivo imaging and mechanical analysis, finding that fibrotic lungs show reduced airspace enlargement compared to healthy lungs after injurious ventilation.

Vimentin networks at high strains

This study investigates the mechanical behavior of vimentin intermediate filament networks under high strain, finding strain stiffening behavior in contrast to actin networks that strain soften.

Brain-derived synaptic vesicles have an intrinsic ability to sequester tubulin

The paper shows synaptic vesicles from mouse brains can sequester soluble tubulin in vitro, forming tubulin-rich regions.

Condensates of synaptic vesicles and synapsin are molecular beacons for actin sequestering and polymerization

The paper investigates how synapsin-SV condensates organize presynaptic actin through LLPS, revealing their role in SV clustering and actin polymerization in lamprey and mammalian synapses.

The Keratin Cortex Stabilizes Cells at High Strains

This study investigates the mechanical role of keratin cortex in epithelial cells by comparing keratin-deficient and wild-type cells under strain.

The Coding And Small-Non-Coding Hippocampal Synaptic RNAome

The paper isolates synaptic RNA from hippocampal neurons and identifies microRNAs that regulate the synaptic mRNAome, suggesting astrocytic contribution and dynamic regulation.