A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA
Jonas Aretz, Gayathri Jeyasankar, Anna Salerno-Kochan, Maren Thomsen, Gabriel Thieulin‐Pardo, Tasir S. Haque, Edith S. Monteagudo, Dan P. Felsenfeld, Michael Finley, Thomas Vogt, Julien Boudet, Brinda C. Prasad
This study identifies a FAN1 mutation linked to faster Huntington's disease progression and shows it disrupts PCNA-mediated FAN1 assembly on DNA.
Nature Communications · May 14, 2025Peer-reviewedBiophysics