Author

Dan P. Felsenfeld

CHDI FoundationORCID 0000-0003-4044-459XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Thomas VogtiD· 3 shared Alessio MurgiaiD· 1 shared Andrea FalquiiD· 1 shared Andrea ScolziD· 1 shared Angela BachiiD· 1 shared Angela Cattaneo· 1 shared Anna Salerno-KochaniD· 1 shared Brinda C. PrasadiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersNeuroscience

Thomas VogtORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJul 27, 2026

Structure-function dissection of huntingtin exon 1 identifies a PRD-driven modifier of neuronal toxicity in Huntington's disease

Raffaele Iennaco, Camilla Maffezzini, Simone Maestri…·Elena F. Cattaneo

The paper identifies the proline-rich domain (PRD) of HTT exon 1 as a modifier of neuronal toxicity in Huntington's disease, showing that the human PRD exacerbates while the mouse PRD mitigates toxicity.

DOI 10.64898/2026.07.23.740298

humanmouse

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BiophysicsNature CommunicationsPeer-reviewedMay 14, 2025

A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA

Jonas Aretz, Gayathri Jeyasankar, Anna Salerno-Kochan…·Brinda C. Prasad

This study identifies a FAN1 mutation linked to faster Huntington's disease progression and shows it disrupts PCNA-mediated FAN1 assembly on DNA.

6 citations

humanstructural biology

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Cell BiologyNeurobiology of DiseasePeer-reviewedApr 19, 2025

Intersecting impact of CAG repeat and Huntingtin knockout in stem cell-derived cortical neurons

Jennifer T. Stocksdale, Matthew Joseph Leventhal, Stephanie Lam…·Leslie Michels Thompson

This study compares the effects of HTT knockout and CAG repeat expansion in cortical neurons, identifying shared and distinct biological pathways involved in HD.

4 citations

humanbulk RNA-seq

𝕏 PostBluesky