BioinformaticsG3 Genes Genomes GeneticsPeer-reviewed
Model-based inference of gene expression noise from single-cell RNA-sequencing data
Fernanda Giersdorf, David W. Rogers, Sören Christensen, Julien Yann Dutheil
This paper introduces a maximum-likelihood framework to estimate gene expression noise from scRNA-seq data, accounting for technical noise and cell type heterogeneity, and demonstrates its reproducibility using yeast data.