Single nucleus transcriptome of a "Super RV" shows increased insulin and angiogenesis signaling
Diwakar Turaga, Xiao Li, Yi Zhao, Chang-Ru Tsai, Axel Moreira, Edward J. Hickey, Iki A. Adachi, James F. Martin
The paper presents the single-nucleus transcriptome of a systemic right ventricle from a patient with congenitally corrected transposition of great arteries, identifying increased insulin and angiogenesis signaling as potential beneficial adaptations to pressure overload.
bioRxiv · Nov 28, 2023 · PreprintDevelopmental Biology