Chang-Ru Tsai

This study identifies distinct cellular processes in end-stage pediatric HCM using single-nucleus RNA sequencing, highlighting activated fibroblasts and stressed cardiomyocytes.

The paper presents the single-nucleus transcriptome of a systemic right ventricle from a patient with congenitally corrected transposition of great arteries, identifying increased insulin and angiogenesis signaling as potential beneficial adaptations to pressure overload.

This study shows that Hippo-deficient cardiac fibroblasts differentiate into osteochondroprogenitors and interact with macrophages, promoting fibrosis through CSF1 signaling.

This study identifies Pvr and Pvf1 as essential for hemocyte spreading at Drosophila larval wound sites and identifies downstream factors involved in wound responses.